Tweetie for Mac users have been able to activate keyword filtering for more than a year using a simple Terminal hack. For all those who prefer a graphical interface to a command line hack, however, TweetiePrefs is here to help.
Developed by Ash White and available for free here, TweetiePrefs lives in System Preferences and allows you to easily create, delete and activate filters for Tweetie. Every time you’ll create or delete a filter, you’ll have to relaunch Tweetie for changes to take effect.
Works fine, and it’s easy to use. Give it a try.