Well, not just for mobile devices:
“Less Framework is a CSS framework for building flexible multi-column website layouts. It contains an eight-column grid optimized for a line-height of 24px, as well as a set of typography presets based on the golden ratio that fit into the grid’s vertical rhythm.
Less Framework layouts work perfectly in Chrome, Safari 3.0+, Firefox 3.0+ and Internet Explorer 7+. They collapse intelligently into a single column in legacy browsers and on small screens.
The best example of Less Framework in use is this very site. Try resizing your browser window or accessing this site with different devices, like your mobile phone.”
Excellent.